USPTO Patents Application 10551504

INTERNATIONAL SEARCH REPORT

COPY SUBMITTED IN IDS

International application Mo.

PCT/JP03/13063

A. CLASSIHCATION OF SUBJECT MATTER

Int-Cl 7 C07K16/18, C12P21/08, A61K39/395, A61P35/00, A61P37/02,
A61P43/00

According to International Patent Qassification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED _ _ _

Minimum documentation searched (classification system followed by classification symbols)

Int. CI 7 C07K16/18, C12P21/08, A61K39/395, A61P35/00, A61P37/02,
A61P43/00

Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched

Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)
WPI {DIALOG), BIOSIS (DIALOG) , JSTPlusu { JOIS) ,
GeneBank/EMBL / DDBCT/ GeneSeq, Swi s sPr o t /PIR/Gene S eq

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category*

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

X
A

X
A

X
A

GENESTIER L. et al . , Fas -independent apoptosis of
activated T cells induced by antibodies to the HLA
class I al domain., Blood 1997, Vol.90, No. 9,
pages 3629 to 3639

MATSDOKA S. et al., A novel type of cell death of
lymphocytes induced by monoclonal antibody without
participation of complement., J. Exp. Med. 1995,
Vol.181, No. 6, pages 2007 to 2015

FA YEN J. et al., Negative signaling by anti-HLA
class I antibodies is dependent upon two triggering
events.. Int. Immunol. 1998, Vol.10, No. 9,
pages 1347 to 1358

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4-23

1-3
4-23

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4-23

|x| Further documents arc listed in the continuation of Box C j j See patent family annex.

* Special categories of cited documents:

"A" document defining tbe general state of the art which is not

considered to be of particular relevance
"E" earlier document but published on or after the international filing

date

"L" document which may throw doubts on priority claim(s) or which ii
cited to establish the publication date of another citation or other
special reason {as specified)

"OP document referring to an oral disclosure, use, exhibition or other
means

"P" document published prior to the international filing date but later
than the priority date claimed

"T" later document published after the international firing date or
priority date and not in conflict with the application but cited to
understand the principle or theory underlying the invention

"X" document of particular relevance; the claimed invention cannot be
considered novel or cannot be considered to involve an inventive
step when the document is taken alone

"Y" document of particular relevance; the claimed invention cannot be
considered to involve an inventive step when the document is
combined with one or more other such documents, such
combination being obvious to a person skilled in the ait
document member of the same patent family

Date of the actual completion of the international search
05 November, 2003 (05.11.03)

Name and mailing address of the ISA/

Japanese Patent Office

Facsimile No.

Form PCT/ISAQ10 (second sheet) (July 1998)

Date of mailing of the international search report

18 November, 2003 (18.11.03)

Authorized officer

Telephone No.

COPY SUBMITTED IN IDS

INTERNATIONAL SEARCH REPORT

International application No.

PCT/JP03/13063

C (Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT

Category*

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

Y
A

Y
A

Y
A

ONO K. et al., The humanized anti-HMl. 2 4 antibody
effectively kills multiple myeloma cells by human
effector cell-mediated cytotoxicity., Mo 1. Immunol.
1999, Vol.36, No. 6, pages 387 to 395

OHTOMO T. et al . , Molecular cloning and charac-
terization of a surface antigen preferentially
overexpressed on multiple myeloma cells., Biochem.
Biophys .Res .Commun. 1999, Vol.258, No. 3, pages 583
to 591

02AKI S. et al.. Humanized anti-HMl. 24 antibody
mediates myeloma cell cytotoxicity that is enhanced
by cytokine stimulation of effector cells . ,
Blood 1999, Vol.93, No. 11, pages 3922 to 3930

1-4
5-23

1-4
5-23

1-4

5-23

Form PCT/ISA/210 (continuation of second sheet) (July 1998)